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PATENTS & PUBLICATIONS

PATENTS

Method for the manufacture of recombinant trypsin
granted by: EP 1 250 442; SG 90540; US 7,351,549

Bioactive oligopeptides
granted by: US 7,101,664

SELECTED PUBLICATIONS

Wolzt M, Gouya G, Sator M, Hemetsberger T, Irps C, Rettenbacher M, Vcelar B (2016) Comparison of pharmacokinetic and safety profiles between Bemfola® and Gonal-f® after subcutaneous application. Eur J Drug Metab Pharmacokinet 41(3):259-65

Zboray K, Sommeregger W, Bogner E, Gili A, Sterovsky T, Fauland K, Grabner B, Stiedl P, Moll HP, Bauer A, Kunert R, Casanova E (2015) Heterologous protein production using euchromatin-containing expression vectors in mammalian cells. Nucleic Acids Res 43(16):e102

Ladenstein R, Weixler S, Baykan B, Bleeke M, Kunert R, Katinger D, Pribill I, Glander P, Bauer S, Pistoia V, Michon J, Garaventa A, Lode HN (2013) Ch14.18 antibody produced in CHO cells in relapsed or refractory Stage 4 neuroblastoma patients: A SIOPEN Phase 1 study. MAbs 5(5):801-9

Katinger D, Jeffs S, Altmann F, Cope A, McKay P, Almond N, Sandström E, Hejdeman B, Biberfeld G, Nilsson C, Hallengärd D, Wahren B, Lehner T, Singh M, Lewis DJ, Lacey C, Shattock R (2012) CN54gp140: product characteristics, peclinical and clinical use - recombinant glycoprotein for HIV immunization. Retrovirology 9 (Suppl 2):351

Reinhart D, Weik R, Kunert R (2012) Recombinant IgA production: single step affinity purification using camelid ligands and product characterization. J Immunol Methods 378(1-2):95-101

Reinhart D, Weik R, Kunert R (2011) 3D6 and 4B3: Recombinant expression of two anti-gp41 antibodies as dimeric and secretory IgA. BMC Proceedings 5 (Suppl 8):56

Kunert R, Gach J, Katinger H (2008) Expression of a Fab fragment in CHO and Pichia pastoris. BioProcess International 6(6):34-40

Gach J, Maurer M, Hahn R, Gasser B, Mattanovich D, Katinger H, Kunert R (2007) High level expression of a promising anti-idiotypic antibody fragment vaccine against HIV-1 in Pichia pastoris. J Biotechnol. 128(4):735-46

Gasser B, Sauer M, Maurer M, Stadlmayr G, Mattanovich D (2007) Transcriptomics-based identification of novel factors enhancing heterologous protein secretion in yeasts. Appl Environ Microbiol 73(20):6499-507

Lattenmayer C, Löschel M, Schriebl K, Sterovsky T, Trummer E, Vorauer-Uhl K, Müller D, Katinger H, Kunert R (2007) Protein-free transfection of CHO host cells with an IgG-fusion protein-selection and characterisation of stable high producers and comparison to conventionally transfected clones. Biotechnol Bioeng 96(6):1118-26

Reisinger H, Sevcsik E, Vorauer-Uhl K, Lohner K, Katinger H, Kunert R (2007) Serum-free transfection of CHO-cells with tailor-made unilamellar vesicles. Cytotechnology 54(3):157-68

Gasser B, Maurer M, Gach J, Kunert R, Mattanovich D (2006) Engineering of Pichia pastoris for improved production of antibody fragments. Biotechnol Bioeng 94(2):353-61

Maurer M, Kuhleitner M, Gasser B, Mattanovich D (2006) Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris. Microb Cell Fact 5:37

Trummer E, Fauland K, Seidinger S, Schriebl K, Lattenmayer C, Kunert R, Vorauer-Uhl K, Weik R, Borth N, Katinger H, Müller D (2006) Process parameter shifting: Part I. Effect of DOT, pH and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors. Biotechnol Bioeng 94(6):1033-44

Trummer E, Fauland K, Seidinger S, Schriebl K, Lattenmayer C, Kunert R, Vorauer-Uhl K, Weik R, Borth N, Katinger H, Müller D (2006) Process parameter shifting: Part II. Biphasic cultivation - a tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells. Biotechnol Bioeng 94(6):1045-52

Böhm E, Grillari J, Voglauer R, Gross S, Ernst W, Ferko B, Kunert R, Katinger H, Borth N (2005) Establishment of a strategy for the rapid generation of a monoclonal antibody against the human protein SNEV (hNMP200) by flow-cytometric cell sorting. J Immunol Methods 307(1-2):13-23

Borth N, Mattanovich D, Kunert R, Katinger H (2005) Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line. Biotechnol Prog 21(1):106-11

Zeng Y, Fest S, Kunert R, Katinger H, Pistoia V, Michon J, Lewis G, Ladenstein R, Lode HN (2005) Anti-neuroblastoma effect of ch14.18 antibody produced in CHO cells is mediated by NK-cells in mice. Mol Immunol 42(11):1311-9

Hohenblum H, Gasser B, Maurer M, Borth N, Mattanovich D (2004) Effects of gene dosage, promoters and substrates on unfolded protein stress of recombinant Pichia pastoris. Biotechnol Bioeng 85:367-75

Hohenblum H, Vorauer-Uhl K Katinger H, Mattanovich D (2004) Bacterial expression and refolding of human trypsinogen. J Biotechnol 109:3-11

Kunert R, Wolbank S, Chang M, Voglauer R, Borth N, Katinger H (2004) Control of key parameters in developing mammalian production clones. BioProcess International 2(6):54-9

Mattanovich D, Gasser B, Hohenblum H, Sauer M (2004) Stress in recombinant protein producing yeasts. J Biotechnol 113(1-3):121-35

Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, Wilson IA (2003) Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science 300(5628):2065-71

Dürrschmid M, Landauer K, Simic G, Klug H, Keijzer T, Trampler F, Oudshoorn A, Gröschl M, Müller D, Doblhoff-Dier O (2003) Comparison of fluidized bed and ultrasonic cell-retention systems for high cell density mammalian cell culture. Biotechnol Prog 19(3):1045-8

Hohenblum H, Borth N, Mattanovich D (2003) Assessing viability and cell-associated product of recombinant protein producing Pichia pastoris with flow cytometry. J Biotechnol 102:281-90

Naschberger S, Rütten K, Müller D, Katinger H (2003) Softmix, a new scalable mixing system for the cultivation of sensitive cells on microcarrier under protein-free conditions. Proceedings of the 18th ESACT Meeting (Granada) – Animal Cell Technology: Animal Cell Technology Meets Genomics:735-8

Trummer E, Müller D, Steinfellner W, Kunert R, Steindl F, Hesse F, Katinger H (2003) Characterisation of CHO subclones showing profound changes in performance when propagated in different cultivation systems. Proceedings of the 18th ESACT Meeting (Granada) – Animal Cell Technology: Animal Cell Technology Meets Genomics:529-32

Jursik C, Voglauer R, Grillari J, Hemetsberger T, Jungfer H, Katinger H (2002) Killer T cells: a promising new tool for adoptive immunotherapy. Transplant Proc 34(7):2879-80

Kunert R, Katinger H (2002) Production of immunoglobulins and monoclonal antibodies targeting infectious diseases. In: Infectious Diseases; Ed.: Georgiev V, Humana Press, pp. 63-99

Soriano E, Borth N, Katinger H, Mattanovich D (2002) Optimization of recombinant protein expression level in Escherichia coli by flow cytometry and cell sorting. Biotechnol Bioeng 80:93-9

Grillari J, Fortschegger K, Grabherr RM, Hohenwarter O, Kunert R, Katinger H (2001) Analysis of alterations in gene expression after amplification of recombinant genes in CHO cells. J Biotechnol 87(1):59-65

Hohenblum H, Naschberger S, Weik R, Katinger H, Mattanovich D (2001) Production of recombinant human trypsinogen in Escherichia coli and Pichia pastoris. A comparison of expression systems. In: Production of recombinant proteins with prokaryotic and eukaryotic cells. Eds.: Merten OW, Mattanovich D, Cole J, Lang C, Larsson G, Neubauer P, Porro D, Postma P, Teixeira de Mattos J, Kluwer Academic Publ, pp. 339-46

Borth N, Zeyda M, Kunert R, Katinger H (2000) Efficient selection of high-producing subclones during gene amplification of recombinant Chinese hamster ovary cells by flow cytometry and cell sorting. Biotechnol Bioeng 71(4):266-73

Franek F, Hohenwarter O, Katinger H (2000) Plant protein hydrolysates: Preparation of defined peptide fractions promoting growth and production in animal cells cultures. Biotechn Prog 16(5):688-92

Kunert R, Steinfellner W, Purtscher M, Assadian A, Katinger H (2000) Stable recombinant expression of the anti HIV-1 monoclonal antibody 2F5 after IgG3/IgG1 subclass switch in CHO cells. Biotechnol Bioeng 67(1):97-103

Müller D, Unterluggauer F, Kreismayr G, Wiederkum S, Hohenwarter O, Schmatz C, Vorauer-Uhl K, Assadian A, Doblhoff-Dier O, Katinger H (2000) Online controlled perfused fluidized bed and fed-batch production. Proceedings of the Cell Culture Engineering VII, Santa Fe, USA

Borth N, Strutzenberger K, Kunert R, Steinfellner W, Katinger H (1999) Analysis of changes during subclone development and ageing of human antibody-producing heterohybridoma cells by northern blot and flow cytometry. J Biotechnol 67(1):57-66

Müller D, Doblhoff-Dier O, Katinger H (1999) Non-invasive adaptive control of the feed rate for high cell density CHO cultures according to the pO2 profile. Proceedings of the 16th ESACT Meeting (Lugano) - Animal Cell Technology: Products from Cells, Cells as Products:171-3

Soriano E, Borth N, Katinger H, Mattanovich D (1999) Flow cytometric analysis of metabolic stress effects due to recombinant plasmids and proteins in Escherichia coli production strains. Metabolic Eng 1:270-4

Strutzenberger K, Borth N, Kunert R, Steinfellner W, Katinger H (1999) Changes during subclone development and ageing of human antibody-producing recombinant CHO cells. J Biotechnol 69(2-3):215-26

Weik R, Striedner G, Francky A, Raspor P, Bayer K, Mattanovich D (1999) Induction of oxidofermentative ethanol formation in recombinant cells of Saccharomyces cerevisiae yeasts. Food Technol Biotechnol 37:191-4

Zeyda M, Borth N, Kunert R, Katinger H (1999) Optimization of sorting conditions for the selection of stable, high-producing mammalian cell lines. Biotechnol Prog 15(5):953-7

Borth N, Mitterbauer R, Mattanovich D, Kramer W, Bayer K, Katinger H (1998) Flow cytometric analysis of bacterial physiology during induction of foreign protein synthesis in recombinant Escherichia coli cells. Cytometry 31:125-9

Kunert R, Rüker F, Katinger H (1998) Molecular characterization of five neutralizing anti-HIV type 1 antibodies: identification of nonconventional D segments in the human monoclonal antibodies 2G12 and 2F5. AIDS Res Hum Retroviruses 14(13):1115-28

Mattanovich D, Kramer W, Lüttich Ch, Weik R, Bayer K, Katinger H (1998) Rational design of an improved induction scheme for recombinant Escherichia coli. Biotechnol Bioeng 58:296-8

Müller D, Schmatz C, Weik R, Wiederkum S, Katinger D, Unterluggauer F, Kreismayr G, Koller G, Doblhoff-Dier O, Katinger H (1998) Perfused fluidised bed production, expanded bed affinity purification and validation (Contract or licensing) Manufacture of clinical grade (CHO-recombinant human) mAbs or other recombinant proteins. Proccedings of the 10th Annual Meeting of Japanese Association for Animal Cell Technology JAACT

Weik R, Francky A, Striedner G, Raspor P, Bayer K, Mattanovich D (1998) Recombinant expression of alliin lyase from garlic (Allium sativum L.) in bacteria and yeasts. Planta Medica 64:387-8

Klima G, Kreismayr G, Müller D, Schmatz C, Wiederkum S, Steinfellner W, Assadian A, Lhota G, Blüml G, Doblhoff-Dier O, Katinger H (1997) Process development for the large scale production of clinical grade human monoclonal antibody using a Cytopilot fluidised bed reactor. Proceedings of the 14th ESACT Meeting (Vilamoura): Animal Cell Technology: From Vaccines to Genetic Medicine:447-50

Müller D, Kreismayr G, Klima G, Assadian A, Schmatz C, Wiederkum S, Steinfellner W, Blüml G, Doblhoff-Dier O, Katinger H (1997) Scale-up optimisation based on the development of a perfusion rate control for CHO cells using a Cytopilot Mini fluidised bed reactor. Proceedings of the 14th ESACT Meeting (Vilamoura): Animal Cell Technology: From Vaccines to Genetic Medicine:451-4

Katinger H, Assadian A, Blüml G, Borth N, Buchacher A, Doblhoff-Dier O, Gaida T, Reiter M, Schmatz C, Strutzenberger K, Steinfellner W, Unterluggauer F, Zach N (1996) Long term stability of continuously perfused animal cells immobilized on novel macroporous microcarriers. Advances in Molecular and Cell Biology 15A:193-207

Mattanovich D, Weik R, Thim S, Kramer W, Bayer K, Katinger H (1996) Optimization of recombinant gene expression in Escherichia coli. Ann NY Acad Sci 782:182-90

Buchacher A, Predl R, Strutzenberger K, Steinfellner W, Trkola A, Purtscher M, Gruber G, Tauer C, Steindl F, Jungbauer A (1994) Generation of human monoclonal antibodies against HIV-1 proteins; electrofusion and Epstein-Barr virus transformation for peripheral blood lymphocyte immortalization. AIDS Res Hum Retroviruses 10(4):359-69

Unterluggauer F, Doblhoff-Dier O, Tauer C, Jungbauer A, Gaida T, Reiter M, Schmatz C, Zach N, Katinger H (1994) Stable continuous large scale production of human monoclonal HIV-1 antibody using a computer controlled pilot plant. Biotechniques 16(1):140-7

MEET US AT

5th International mRNA Health Conference
November 1-2, 2017

Berlin, Germany

Dr. Andreas Wagner
Dr. Charalampos Koutsoulas
 

EuroTIDES
November 7-10, 2017

Vienna, Austria

Dr. Andreas Wagner
Dr. Charalampos Koutsoulas
Harald Loidl, BSc
Frances Aichinger, BSc