Polymun has transformed liposomes from a promising scientific idea into a sound industrial solution. The production technology is suitable for a broad range of substances formulated by passive entrapment, active loading or membrane incorporation.
Main characteristics of our technology
The injection module is the heart of the liposome production. The process parameters determine the size of the liposomes regardless of the scale. Production of 250 liters of liposome preparation takes only 1.5 hour. Large scale also can be achieved by using several injection modules in parallel.
SINGLE STEP PROCESS
Liposome size is adjusted by modulating the process parameters during vesicle formation. No additional downsizing is required.
A closed system is used for production. All components can be added via sterile filtration. Subsequent concentration by crossflow filtration is possible as well.
HOMOGENEOUS, UNIFORM VESICLES
All process parameters are controlled precisely. This results in a very narrow size distribution, necessary for reliable targeting and transport characteristics.
EXCELLENT BATCH TO BATCH CONSISTENCY
High quality of raw materials and precisely controlled process parameters guarantee excellent reproducibility – essential for pharmaceutical products.
MILD PROCEDURE – STABILITY
The crossflow injection technique is a very mild procedure that allows the processing of sensitive drugs. Together with the high quality of raw materials and narrow size distribution, we achieve long term stability of liposomes even at room temperature.
- Full Scalability
- Single Step Process
- Aseptic Process
- Homogeneous, Uniform Vesicles
- Excellent Batch to Batch Consistency
- Mild Procedure – Stability
DOWNLOAD LIPOSOMAL BROCHURE
Polymun Liposome Technology
Broschure (pdf, 1MB)