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Liposomal Formulation of Drugs

Polymun has unique know-how and technology for the development and manufacturing of liposomal formulations.

 

Reference Projects

CUSTOMER/PARTNERPRODUCTSCOPE AT POLYMUNSTATUS
Arcturus Therapeutics Inc.
USA
Lipid nanoparticle formulation of mRNA as coronavirus vaccine Implementing of manufacturing process and analytical methods, GMP production
Preclinical
CureVac
Germany
Lipid nanoparticle formulation of surface protein encoding mRNA as coronavirus vaccine Establishing of manufacturing process and analytical methods, GMP production
Phase 1, Europe
BioNTech RNA Pharmaceuticals GmbH
Germany
Lipid nanoparticle formulations of surface protein encoding mRNA and self-amplifying RNA as coronavirus vaccine Establishing of manufacturing process and analytical methods, GMP production
Phase 1, Europe & US
BioNTech RNA Pharmaceuticals GmbH
Germany
Plain liposomes as carrier for mRNA for cell therapy Establishing of manufacturing process and analytical methods, GMP production
Preclinical
BioNTech RNA Pharmaceuticals GmbH
Germany
Lipid nanoparticle formulation of mRNA coding for a therapeutic antibody Establishing of manufacturing process and analytical methods, GMP production
Preclinical
Imperial College London
UK
Lipid nanoparticle formulation of self-amplifying RNA as coronavirus vaccine Establishing of manufacturing process and analytical methods, GMP production
Phase 1, UK
InteRNA Technologies B.V.
The Netherlands
Lipid nanoparticle formulation of miRNA INT-1B3 for treatment of advanced solid tumors Establishing of manufacturing process and analytical methods, GMP production
Preclinical
MiNA Therapeutics Ltd.
UK
Liposomal saRNA MTL-CEBPA with Smarticle technology for cancer treatment Process development, GMP production
Phase 2 ongoing, UK
Mirna Therapeutics Inc.
USA
Liposomal miRNA MRX34 with Smarticle technology for cancer treatment Process development, GMP production
Phase 1, USA
Dicerna Pharmaceuticals, Inc.
USA
Liposomal formulation of siRNA Process development, GMP production
Preclinical and clinical
Wittycell SA
(now Abivax) France
Liposomal adjuvant WTCcFormulation and process development, GMP production
Phase 1/2a, South Africa
AC Immune SA
Switzerland
ACI-24, liposomal Alzheimer’s disease vaccine with MPLA adjuvantProcess development, GMP production
Phase 2 ongoing, Europe
EuroNeut-41, EU FP7 project coordinated by Sanofi-Pasteur
France
Liposomal formulation of HIV membrane protein gp41 and MPLA as HIV vaccineFormulation and process development, GMP production
Phase 1 completed, UK
Signpath Pharma
USA
Liposomal formulation of curcumin for the treatment of cancerFormulation and process development, GMP production
Phase 1 completed, Phase Ib completed, Austria
ProNAi Inc.
USA
Liposomal of DNAi PNT100 with Smarticle technology for cancer treatment Process development, GMP production
Phase 2 completed, USA
Sanochemia Pharmazeutika AG
Austria
Liposomal formulation of galantamine for the treatment of neuropathic painFormulation and process development, GMP production
Phase 1/2a completed, Bulgaria

CUSTOMER/PARTNER

Arcturus Therapeutics Inc.
USA

PRODUCT

Lipid nanoparticle formulation of mRNA as coronavirus vaccine

SCOPE AT POLYMUN

Implementing of manufacturing process and analytical methods, GMP production

STATUS

Preclinical

CUSTOMER/PARTNER

CureVac
Germany

PRODUCT

Lipid nanoparticle formulation of surface protein encoding mRNA as coronavirus vaccine

SCOPE AT POLYMUN

Establishing of manufacturing process and analytical methods, GMP production

STATUS

Phase 1, Europe

CUSTOMER/PARTNER

BioNTech RNA Pharmaceuticals GmbH
Germany

PRODUCT

Lipid nanoparticle formulations of surface protein encoding mRNA and self-amplifying RNA as coronavirus vaccine

SCOPE AT POLYMUN

Establishing of manufacturing process and analytical methods, GMP production

STATUS

Phase 1, Europe & US

CUSTOMER/PARTNER

BioNTech RNA Pharmaceuticals GmbH
Germany

PRODUCT

Plain liposomes as carrier for mRNA for cell therapy

SCOPE AT POLYMUN

Establishing of manufacturing process and analytical methods, GMP production

STATUS

Preclinical

CUSTOMER/PARTNER

BioNTech RNA Pharmaceuticals GmbH
Germany

PRODUCT

Lipid nanoparticle formulation of mRNA coding for a therapeutic antibody

SCOPE AT POLYMUN

Establishing of manufacturing process and analytical methods, GMP production

STATUS

Preclinical

CUSTOMER/PARTNER

Imperial College London
UK

PRODUCT

Lipid nanoparticle formulation of self-amplifying RNA as coronavirus vaccine

SCOPE AT POLYMUN

Establishing of manufacturing process and analytical methods, GMP production

STATUS

Phase 1, UK

CUSTOMER/PARTNER

InteRNA Technologies B.V.
The Netherlands

PRODUCT

Lipid nanoparticle formulation of miRNA INT-1B3 for treatment of advanced solid tumors

SCOPE AT POLYMUN

Establishing of manufacturing process and analytical methods, GMP production

STATUS

Preclinical

CUSTOMER/PARTNER

MiNA Therapeutics Ltd.
UK

PRODUCT

Liposomal saRNA MTL-CEBPA with Smarticle technology for cancer treatment

SCOPE AT POLYMUN

Process development, GMP production

STATUS

Phase 2 ongoing, UK

CUSTOMER/PARTNER

Mirna Therapeutics Inc.
USA

PRODUCT

Liposomal miRNA MRX34 with Smarticle technology for cancer treatment

SCOPE AT POLYMUN

Process development, GMP production

STATUS

Phase 1, USA

CUSTOMER/PARTNER

Dicerna Pharmaceuticals, Inc.
USA

PRODUCT

Liposomal formulation of siRNA

SCOPE AT POLYMUN

Process development, GMP production

STATUS

Preclinical and clinical

CUSTOMER/PARTNER

Wittycell SA
(now Abivax) France

PRODUCT

Liposomal adjuvant WTCc

SCOPE AT POLYMUN

Formulation and process development, GMP production

STATUS

Phase 1/2a, South Africa

CUSTOMER/PARTNER

AC Immune SA
Switzerland

PRODUCT

ACI-24, liposomal Alzheimer’s disease vaccine with MPLA adjuvant

SCOPE AT POLYMUN

Process development, GMP production

STATUS

Phase 2 ongoing, Europe

PRODUCT

Liposomal formulation of HIV membrane protein gp41 and MPLA as HIV vaccine

SCOPE AT POLYMUN

Formulation and process development, GMP production

STATUS

Phase 1 completed, UK

CUSTOMER/PARTNER

Signpath Pharma
USA

PRODUCT

Liposomal formulation of curcumin for the treatment of cancer

SCOPE AT POLYMUN

Formulation and process development, GMP production

STATUS

Phase 1 completed, Phase Ib completed, Austria

CUSTOMER/PARTNER

ProNAi Inc.
USA

PRODUCT

Liposomal of DNAi PNT100 with Smarticle technology for cancer treatment

SCOPE AT POLYMUN

Process development, GMP production

STATUS

Phase 2 completed, USA

CUSTOMER/PARTNER

Sanochemia Pharmazeutika AG
Austria

PRODUCT

Liposomal formulation of galantamine for the treatment of neuropathic pain

SCOPE AT POLYMUN

Formulation and process development, GMP production

STATUS

Phase 1/2a completed, Bulgaria